In a medium mixing bowl, whisk together the mayonnaise, Dijon mustard, apple cider vinegar, and Worcestershire sauce until smooth and creamy.
Add the freshly cracked black pepper, garlic powder, onion powder, smoked paprika, kosher salt, and cayenne pepper, if using.
Whisk until all of the spices are evenly incorporated and the sauce has a smooth, creamy consistency.
Taste the sauce and adjust the seasoning with additional black pepper, vinegar, or salt if needed.
Transfer the sauce to an airtight container or mason jar.
Refrigerate for at least 30 minutes to allow the flavors to develop and the sauce to thicken slightly.
Stir the sauce well before serving to redistribute the seasonings.
Spread on burgers, patty melts, sandwiches, wraps, or serve as a dipping sauce for fries, onion rings, chicken tenders, and grilled vegetables.